Humboldt-Universität zu Berlin - Mathematisch-Naturwissenschaftliche Fakultät - Institut für Chemie

Humboldt-Universität zu Berlin | Mathematisch-Naturwissenschaftliche Fakultät | Institut für Chemie | Aktuelles / News | Biomimetic Chemistry: Structural Insight into Enzymatic Intermediate

Biomimetic Chemistry: Structural Insight into Enzymatic Intermediate

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A highly reactive S=2 pseudotetrahedral oxoiron(IV) complex supported by a sterically demanding 1,4,7-tri-tert-butyl-1,4,7-triazacyclononane ligand has been synthesized and spectroscopically characterized as one of the best electronic and functional models for a biological oxoiron(IV) intermediate of taurine dioxygenase (TauD-J).  This study from Kallol Ray, Marcel Swart and coworkers provide insights into the long elusive structure of TauD-J. The paper was recently published in Angewandte Chemie as a Hot Paper.  (see: Warm et al. Angew. Chem. Int. Ed. 2021, 60, 6752 – 6756)