Humboldt-Universität zu Berlin - Mathematisch-Naturwissenschaftliche Fakultät - Institut für Chemie

Lipid Transport in the Spotlight

The Arenz group developed an efficient and miniaturized assay to monitor the transport of a certain lipid in living cells. This has been achieved by genetically engineering a fusion protein consisting of the ceramide transfer protein (CERT) and Nanoluciferase, a bioluminescence generating enzyme. The assay helped in identifying potent inhibitors with potential to treat an inborn form of severe intellectual disability.

 

 

Link to the publication:

https://doi.org/10.1002/anie.202413562