Lipid Transport in the Spotlight
The Arenz group developed an efficient and miniaturized assay to monitor the transport of a certain lipid in living cells. This has been achieved by genetically engineering a fusion protein consisting of the ceramide transfer protein (CERT) and Nanoluciferase, a bioluminescence generating enzyme. The assay helped in identifying potent inhibitors with potential to treat an inborn form of severe intellectual disability.
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