Humboldt-Universität zu Berlin - Faculty of Mathematics and Natural Sciences - Bioorganic Synthesis

 

 

Chemical Protein Synthesis

Why is it interesting?

Posttranslational modifications are nature’s way to regulate protein function. Chemical protein synthesis is the prime method to access proteins with defined posttranslational modifications including, amongst others, phosphorylation, glycosylation and fatty acid modification.

What are we doing?

To gain access to proteins, the field relies on segment coupling enabled by the native chemical ligation (NCL, see Figure 1). This key enabling technique NCL is having a huge impact on the protein sciences. There are, however, bottlenecks that we address in our research.

more...

 

 

Our contributions: