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Why is it interesting? If interactions between a receptor and a ligand are weak, nature frequently takes recourse to multivalency to enable a high collective affinity by interactions between multiple binding sites and multiple ligands. This principle allows the design of high affinity binders. We think oligonucleotides are the ideal scaffolds to precisely arrange ligands in space through the programed self-assembly of oligonucleotide conjugates. DNA-programmed spatial screening provides on the one hand information about the distance of binding sites on biological receptor systems and on the other hand affords high affinity binders. |
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What are we doing? We address one of the greatest challenges in cancer therapy: the localization of a cytotoxic or imaging effect to a tumor with minimal activity in surrounding healthy tissue. |
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