Humboldt-Universität zu Berlin - Faculty of Mathematics and Natural Sciences - Department of Chemistry

Selected Organometallics in Organic Synthesis

Why organometallic synthetic chemistry?

Lithium compounds: Recent developments - handling and applications.

Organomagnesium compounds - carbomagnesation -enantioselective carbomagnesation - Cu-catalyzed 1.4-addition with Grignard reagents - Kulinkovich reaction.

Organoboron chemistry - preparation of organoboron compounds - hydroboration - metal catalyzed hydroboration - chiral organoboranes - alkylation of carbonyl compounds - homoallylic alcohols via allylboranes.

Organoaluminium compounds - reactivity - mobility of ligands - oxygenophilicity - reactivity of ate complexes - hydroalumination - carboalumination - stereoselectivity in alkylation processes of carbonyl compounds - reactions with epoxides - 1.4-addition.

Hydrozirconation - ring forming and ring opening reactions - acyl zirconocenes - reactions with aldehydes- 1.2 and 1.4-additions - enantioselective palladium catalyzed additions - MOP - allylation.

Titanium(IV)-alkoxides, amides - regio- and stereoselectivity in alkylation reactions,
titanium(IV)-allylcomplexes - Kulinkovic-reaction - olefin metathesis.

Palladium(II) - complexes: additions of oxygen, carbon and nitrogen nucleophiles, allylic rearrangements - ortho-palladation - cycloisomerization.

Palladium(0) - complexes: transmetallation -oxydative addition - insertion reactions - allylic alkylation.

Beller / Bolm: "Transition Metals for Organic Chemistry" I and II.
Schlosser: "Organometallics in Synthesis / A Manual".
Marek: "Titanium and Zirconium in Organic Synthesis".
Elschenbroich: "Organometallchemie".
Hegedus: "Transitionmetal chemistry".
Komiya: "Synthesis of Organometallic Compounds".
Richey: "Grignard Reagents - New Developments".

M. Hesse, H. Meier, B. Zeeh: "Spektroskopische Methoden in der Organischen Chemie", Thieme-Verlag.
D. H. Williams, I. Fleming: "Strukturaufklärung in der organischen Chemie", Thieme-Verlag 1991.