Humboldt-Universität zu Berlin - Mathematisch-Naturwissenschaftliche Fakultät - Institut für Chemie

Selective Catalytic Hydrofluorination of Alkynes



The Braun group has developed unprecedented Pt catalyzed catalytic hydrofluorination reactions to yield (Z)-fluoroalkenes. Model reactions show that water and air stable Pt(ii)-fluorido complexes bearing 2-(3-methyl)indolylphosphine ligands can activate alkynes at the metal centre. The fluoride is then bound in a hydrogen bonding network in the outer coordination sphere allowing for a subsequent C-F bond formation. (Z)-fluoroalkenes are considered as isosteric building blocks to a peptide moiety.


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